C Cell Host & Microbe · Dec 01, 2025 Lantibiotic-producing bacteria impact microbiome resilience and colonization resistance Lantibiotic-producing gut commensals are prevalent in human gut microbiomes. Cole et al. demonstrate that gut colonization with lantibiotic-producingBlautia pseudococcoidesSCSK (BpSCSK) prevents recovery of antibiotic-induced dysbiosis and increases susceptibility toKlebsiella pneumoniaeandClostridioides difficileinfection. biology
C Cell Host & Microbe · Dec 01, 2025 Diet modulatesVibrio choleraecolonization and competitive outcomes with the gut microbiota Liu et al. show that dietary protein sources differentially restrict colonization of the pathogenVibrio cholerae. Specific diets downregulateV. choleraetype VI secretion system (T6SS) expression, leading to the loss of pathogen competitiveness against commensal bacteria, as well as alterations in the abundance and composition of the gut microbiota. biology
C Cell Host & Microbe · Dec 01, 2025 A commensal bacterium secretes effector proteins to establish population heterogeneity in the gut Zagieboylo and colleagues demonstrate that the human commensalBacteroides thetaiotaomicronsecretes two self-targeting proteins that induce heterogeneity within its own population. Differential expression of these effectors and a cognate protective factor provide a mechanism by which a single commensal strain diversifies into sub-populations within the gut environment. biology
C Cell Host & Microbe · Dec 01, 2025 Cryptococcusexploits delayed microglial activation, and microglial osteopontin/Spp1impairs peripheral host control Cryptococcal meningoencephalitis (CM) is a leading cause of death in HIV/AIDS. Reyes et al. found that microglial activation is markedly delayed afterCryptococcusinvasion compared withCandida. Microglia require Th1-derived IFN-γ for activation, and their osteopontin expression worsens disease—revealing a deficient microglial response that permits brain infection. biology mouse experiments
