Daily Picks from Nature, Cell, Science, PNAS

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Immunity · Dec 05, 2025

A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement

While the phospholipid PI4P is implicated in STING activation, its molecular mechanism has remained elusive. Han et al. reveal that PI4P cooperates with the transmembrane agonist GNE-6468 to activate the STING immune response, highlighting its therapeutic potential for immunotherapy.

biology

A chemical agonist and the Golgi-resident lipid P…

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Immunity · Dec 02, 2025

A host-centric view of the microbiota metabolome

Our current understanding of microbial-host communication is largely based on context-dependent examples and anecdotes. Yamada and Palm present a teleological framework that organizes microbial metabolites based on their impacts on the host. These fundamental principles of host-microbe interplay enhance our perspectives of how microbial metabolites influence host immunity and beyond.

biology

A host-centric view of the microbiota metabolome

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Immunity · Dec 01, 2025

Clonal persistence dominates homeostatic intestinal IgA responses

Gut plasma cells secrete IgA, which prevents infections, neutralizes toxins, and regulates the gut microbiota. Simons et al. demonstrate that stable IgA production results not from the persistence of individual plasma cells but rather a continuous dynamic renewal of the gut plasma cell population through diversification of large B cell clones.

biology

Clonal persistence dominates homeostatic intestin…

Latest Articles

A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement

A host-centric view of the microbiota metabolome

Clonal persistence dominates homeostatic intestinal IgA responses