We describe a compositionally guided structural evolution within a stoichiometrically conserved framework, BaSbQ3 (Q = Te1−xSx), where each value of x gives rise to a distinct phase. The fundamental building blocks, A1 (BaSbSTe2) and Bn (BanSbnSn−1Te2n+1)...
Commercializing perovskite photovoltaics requires overcoming three critical barriers: the use of toxic solvents in manufacturing, variations in perovskite film quality across large areas, and limited operational reliability. Here, we address these ...
There are widespread fears that conversational artificial intelligence (AI) could soon exert unprecedented influence over human beliefs. In this work, in three large-scale experiments (N = 76,977 participants), we deployed 19 large language models (LLMs)—...
High-yielding forage grasslands frequently comprise low species diversity and receive high inputs of nitrogen fertilizer. To investigate multispecies mixtures as an alternative strategy, the 26-site international ‘LegacyNet’ experiment systematically ...
Accumulating evidence has connected the chemically unstable, DNA-damaging gut bacterial natural product colibactin to colorectal cancer, including the identification of mutational signatures that are thought to arise from colibactin-DNA interstrand cross-...
The plant cell wall regulates development through spatiotemporal modulation of its chemical and mechanical properties. Pectin methylesterification is recognized as a rheological switch controlling wall stiffness. Here, we reveal a bimodal ...
Whether Nanotyrannus lancensis represents a distinct taxon or an immature Tyrannosaurus rex is a decades-long controversy. The N. lancesis holotype is an isolated skull and ceratobranchials, but limb osteohistology of Nanotyrannus-like individuals ...
Cohesin folds genomes into chromatin loops, the roles of which are under debate. We found that double-strand breaks (DSBs) induce de novo formation of chromatin loops in human cells, with the loop base positioned at the DSB site. These loops form in the ...
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequence to faithfully restore damaged DNA, yet how broken ...
The synthesis of human genomes and other gigabase-scale genomes will require new strategies. Here, we realized key steps in our pipeline for building synthetic human chromosomes. We established: (i) the facile transfer of human chromosomes from human ...
Mucosal associated invariant T (MAIT) cells mediate tissue homeostasis and antimicrobial immunity. However, the cells that express MHC class I-related protein 1 (MR1) and present microbial vitamin B-derived antigens (VitBAg) to MAIT cells remain unknown. ...
According to the Kosterlitz-Thouless-Halperin-Nelson-Young (KTHNY) theory, the transition from a solid to liquid in two dimensions proceeds through an orientationally ordered liquid-like hexatic phase. However, alternative mixed melting scenarios, in ...
The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo–electron tomography and molecular dynamics simulations, we elucidated the structure of phase-separated chromatin condensates across ...
Electrically driven dielectric elastomer artificial muscles represent a transformative advancement in the field of soft robotics. However, their output performance has encountered a bottleneck owing to the insufficient electromechanical sensitivity of ...
Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialization of antibiotics influenced their evolution is limited by a paucity of data predating the antibiotic era (PAE). By investigating plasmids ...
